finally some of the work i was doing at
psl in sydney has been finished and accepted for publication by
biochemical journal. it sure has been a bit of a struggle - plenty of emailed versions back and forth between me in zurich and various people in sydney. now hopefully people will read and like it!
"mucin glycosylation changes in cystic fibrosis lung disease are not manifest in submucosal gland secretions" Biochem. J. (2004) Immediate Publication, doi:10.1042/BJ20041641.
abstract.
so what does it all mean?
people with
cystic fibrosis produce lots of mucous, especially in their lungs, and are very prone to serious and chronic bacterial lung infections. quite a bit of research has been done on the mucous they produce, since their could be something different about cf mucous that makes it easier for bacteria to grow there. one of the main sources of mucous in the lung (everyone's lungs) are the submucosal glands, so we analysed mucous from these glands from people with and without cf. but we didn't find a difference in the glycosylation, even if people had cf, had smoked for 40 years, or were otherwise healthy! so that means that the differences in the glycosylation of mucous in cf are probably caused by the infections they have, not the other way around.